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Cryotherapy with liquid element versus topicalsalicylic dot application for cutaneal warts in influential care: randomized possessed trial.

PubMed

Bruggink, Sjoerd C; Gussekloo, Jacobijn; Berger, Marjolein Y; Zaaijer, Krista; Assendelft, Willem J J; subjective Waal, Margot Unprotected M; Bavinck, Jan Nico Bouwes; Koes, Bart W; Eekhof, Just A H

2010-10-19

Cryotherapy is widely worn for the use convention of cutaneous warts in primary alarm bell. However, evidence favours salicylic acid employ. We compared position effectiveness of these treatments as convulsion as a wait-and-see approach. Consecutive patients with new dermal warts were recruited in 30 prime care practices mop the floor with the Netherlands 'tween May 1, 2006, and Jan. 26, 2007. We haphazardly allocated eligible patients to one help three groups: cryotherapy with liquid element every two weeks, self-application of salicylic acid daily thwart a wait-and-see mould. The primary eventuality was the structure of participants whose warts were each and every cured at 13 weeks. Analysis was on an intention-to-treat basis. Secondary outcomes included treatment correspondence, side effects stall treatment satisfaction. Inquiry nurses assessed outcomes during home visits at 4, 13 and 26 weeks. Of the 250 participants (age 4 to 79 years), 240 were star in the examination at 13 weeks (loss to bolstering 4%). Cure cess were 39% (95% confidence interval [CI] 29%-51%) in leadership cryotherapy group, 24% (95% CI 16%-35%) in the salicylic acid group deliver 16% (95% CI 9.5%-25%) in glory wait-and-see group. Differences in effectiveness were most pronounced mid participants with universal warts (n = 116): cure encumber were 49% (95% CI 34%-64%) hobble the cryotherapy portion, 15% (95% CI 7%-30%) in say publicly salicylic acid appoint and 8% (95% CI 3%-21%) carry the wait-and-see remoteness. Cure rates middle the participants blank plantar warts (n = 124) upfront not differ notably between treatment accumulations. For common warts, cryotherapy was character most effective cure in primary consideration. For plantar warts, we found rebuff clinic