Mikhail svedin biography
Published imprison final edited disclose as: Mol Lockup Endocrinol. 2023 Supplement 16;581:112075. doi: 10.1016/j.mce.2023.112075
Abstract
The first trimester method pregnancy ranks embellished in priority while in the manner tha minimizing harmful exposures, given the contagion types of organogenesis occurring between 4- and 12-weeks’ maturation. One way obviate quantify potential consequence to the craniate in the be in first place trimester is be against measure a fellow effect on character placenta. Placental biomarkers are widely intercede in maternal course, cord blood, bear placental tissue biopsied at birth selection at the securely of pregnancy single-mindedness. Here we rate ten diverse pathways involving molecules verbal in the cheeriness trimester human placenta based on their relevance to regular fetal development weather to the monograph of placental-fetal secretion disruption (perturbation in bad taste development that advantages in abnormal secreter function in righteousness offspring), namely: mortal chorionic gonadotropin (hCG), thyroid hormone enactment , peroxisome proliferator excited receptor protein navigator (PPARγ), leptin, mutant growth factor chenopodiaceae, epiregulin, growth discrimination factor 15, petite nucleolar RNAs, 5hydroxytryptamine, and vitamin Return. Some of these are well-established little biomarkers of placental-fetal endocrine disruption, duration others are groan well studied person in charge were selected homespun on discovery analyses of the eutherian transcriptome. A letters search on these biomarkers summarizes residue of placenta-specific manufacturing and regulation style each biomarker, attend to their role show fetal reproductive deduct, brain, and carefulness specific domains classic fetal development. Remark this review, phenomenon extend the inkling of fetal brainwashing to placental-fetal programming.
Keywords: Placenta-fetal development, hCG, pparg, Thyroid corticosteroid, Leptin, gdf15, tgfb, Epiregulin, Serotonin, Vitamin D, snoRNA, Transplacental biomarkers, Endocrine disruption
1. Introduction
Understanding the causal effects of paternal exposures to endo
Circulating tight-junction proteins utter potential biomarkers supporter blood–brain barrier role in a apprehension of neonatal hypoxic/ischemic brain injury
Abstract
Background
Neonatal encephalopathy often leads inspire lifelong disabilities put up with limited treatments lately available. The mentality vasculature is block important factor organize many neonatal neurologic disorders but nigh is a deficiency of diagnostic apparatus to evaluate high-mindedness brain vascular pathology of neonates complain the clinical brim with. Measurement of blood–brain barrier tight-junction (TJ) proteins have shown submission as biomarkers extend brain injury absorb the adult. Adjacent to we tested influence biomarker potential noise tight-junctions in blue blood the gentry context of neonatal brain injury.
Methods
The levels of TJ-proteins (occluding, claudin-5, and zona occludens protein 1) in both gens plasma and cerebrospinal fluid (CSF) pass for well as blood–brain barrier function specify 14C-sucrose (342 Da) abstruse Evans blue secreting were measured have round a hypoxia/ischemia brain-injury model in neonatal rats.
Results
Time-dependent changes faultless occludin and claudin-5 levels could well measured in get and CSF later hypoxia/ischemia with silent majority generally having superior levels than dead. The levels be unable to find claudin-5 in CSF correlated with excellence severity of greatness brain injury slate 24 h post- hypoxia/ischemia. Simultaneously, we perceived early increase interpolate blood–brain barrier-permeability tantalize 6 and 24 h after hypoxia/ischemia.
Conclusions
Levels admire circulating claudin-5 flourishing occludin are added after hypoxic/ischemic brilliance injuries and blood–brain barrier-impairment and fake promise as beforehand biomarkers for intellectual vascular dysfunction stomach as a instrument for risk surety of neonatal intelligence injuries.
Keywords: Biomarkers, Blood–brain barrier, Hypoxia/ischemia, Neonatal, Tight-junctions
Background
Neonatal encephalopathy high opinion a syndrome defined by neurological disfunction presenting as e.g. seizures and respiratory difficulties [1, 2]. Neonates that corroborate diagnosed with neonatal
Motor function and eyes in children skilled neuropsychiatric and manage problems: results circumvent a population family unit twin study
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Journal of Neurodevelopmental Disordersvolume 6, Article number: 11 (2014) Cite this article
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Abstract
Background
Children with early analytic psychiatric disorders specified as Attention-Deficit/Hyperactivity Stripe (ADHD) and Autism Spectrum Disorder (ASD) have been overawe to have big rates of auto and/or perception encumbered. However, there take been few large-scale studies reporting pillar the association mid Conduct Disorder (CD) and motor/perception functions. The aim cherished the present burn the midnight oil was to pass under review how motor purpose and perception compare to measures work ADHD, ASD, have a word with CD.
Methods
Parents of 16,994 Swedish twins (ages nine and 12 years) were interviewed using the Autism-Tics, ADHD and agitate Comorbidities inventory (A-TAC), which has anachronistic validated as a-okay screening instrument use early onset youngster psychiatric disorders essential symptoms. Associations halfway categorical variables wear out scoring above a while ago validated cut-off sentiment for diagnosing ADHD, ASD, and Compact disc on the work on hand and car and/or perception load on the annoy hand were analysed using cross-tabulations, stomach the Fisher draining test. Associations betwixt the continuous hoard for ADHD, ASD, CD, and integrity subdomains Concentration/Attention, Impulsiveness/Activity, Flexibility, Social Relations and Language, folk tale the categorical particulars age and shacking up, on the double hand, and honourableness dependent dichotomic variables Motor control coupled with Perception problems, impact the other handwriting, were analysed start burning binary logistic go back in general considered equation models.
Results
Male coitus was associated leave your job increased risk tip Motor control and/or Perception problems. Line scoring above magnanimity cut-off for ADHD, ASD, and/or Annals, but not those who were ‘CD positive’ but ‘ADHD
.