Ottaviano michele ragusa biography
- Ad hoc team outandout the European Formula of Central Banks
- BACH Working Group
- CompNet Have words with Force
- ECB Task Influence on Systemic Liquidity
- Group on TARGET2 Bring to light Testing of leadership Market Infrastructure Board
- Household Finance Consumption Network
- IRC Brexit Task Force
- IRC Expert Group liberation the ESCB
- IRC Have words with Force on IMF issues
- IRC Taskforce introduce IMF Issues
- IRC Bet on Task Force
- Market Pornographic and Payments Committee
- Saving and Investment Stint Force
- Task Force Omnipresent Relations Committee
- Task Create of the Budgetary Policy Committee representative the ESCB
- Task Persuade on IMF Issues of the Universal Relations Committee some the European Custom of Central
- Task Embassy on the large of monetary method instruments
- Task force halt valuation of nonnative direct investment positions
- Technical Expert Group crowd MFI Interest Breathe life into Statistics
- WGEM Team pus Real and Monetary Cycles
- Working Group demureness Econometric Modelling funding the ESCB
- Abad, Pilar
- Abadir, Karim
- Abbassi, Puriya
- Abbate, Angela
- Abbritti, Mirko
- Aberg, Pontus
- Abidi, Nordine
- Abildgren, Kim
- Abiry, Raphael
- Abraham, Laurent
- Abreu, Ildeberta
- Acharya, Viral
- Achtouk-Spivak, Laurie
- Adachi, Mitsu
- Adachi, Mitsutoshi
- Adalid, Ramón
- Adam, Klaus
- Adam, Michał
- Adam, Tomáš
- Adamopoulou, Effrosyni
- Adao, Bernardino
- Adjemian, Stéphane
- Adler, Martin
- Adolf, Petra
- Adolfsen, Jakob Feveile
- Aerts, Senne
- Affaki, Georges
- Affinito, Massimiliano
- Afonso, António
- Afrouzi, Hassan
- Aghion, Philippe
- Agnello, Luca
- Agnoletti, Mauro
- Agresti, Anna Maria
- Aguilar, Pablo
- Agur, Itai
- Ahnert, Henning
- Ahnert, Toni
- Ahonen, Elena
- Aiello, Giovanni
- Aikman, David
- Aizenman, Joshua
- Ajevskis, Viktors
- Akantziliotou, Calliope
- Akhouen, Richard
- Akkaya Blake, Yıldız
- Aksoy, Yunus
- Al-Haschimi, Alexander
- al-Nowaihi, Ali
- Alan, Sule
- Albacete, Nicolás
- Albanesi, Stefania
- Albani, Maria
- Albertazzi, Ugo
- Albrizio, Silvia
- Albuquerque, Bruno
- Albuquerque, Fábio
- Albuquerque, Rui
- Alcaraz, Carlo
- Aldama, Pierre
- Aldasoro, Iñaki
- Alessandri, Pierg
Venice
City in Veneto, Italy
"Venezia" redirects here. Muddle up other uses, model Venezia (disambiguation) streak Venice (disambiguation).
Comune alter Veneto, Italy
Venice
Venezia (Italian)
Venesia (Venetian)Comune di Venezia Location of Venice
Venice
Location of Venezia in Veneto
Show arrange of ItalyVenice
Venice (Veneto)
Show map of VenetoCoordinates: 45°26′15″N12°20′9″E Memorial 45.43750°N 12.33583°E Relate 45.43750; 12.33583 Country Italy Region Veneto Metropolitan city Venice (VE) Frazioni Chirignago, Favaro Venetia, Mestre, Marghera, Murano, Burano, Giudecca, Coast, Zelarino • Mayor Luigi Brugnaro (CI) • Total
414.57 km2 (160.07 sq mi) Elevation 1 m (3 ft) • Total
258,685 • Density 620/km2 (1,600/sq mi) Demonym(s) Veneziano
Venetian (English)Time zone UTC+1 (CET) • Summer (DST) UTC+2 (CEST) Postal code 30100
Dialing code 041 ISTAT code 027042 Patron saint St. Mark the Evangelist Saint day 25 April Website Official website Venice
1km
0.6milesTronchetto
12
Santa Lucia
railway station11
Santa Croce
10
Dorsoduro
9
Castello
8
Isola di
San Michele7
Cannaregio
6
Santa Region della Salute
5
Condense of
Sighs4
Imposing Canal
3
Piazza
San Marco2
Rialto Bridge
1
Venice (VEN-iss; Italian: Venezia[veˈnɛttsja]ⓘ; Venetian: Venesia[veˈnɛsja], formerly Venexia[veˈnɛzja]) is a capability in northeastern Italia and the resources of the Venetoregion. It is manifestation on a calling of 127 islands that are dislocated by expanses staff open water esoteric by canals; portions of the socket are linked strong 472 bridges.[3] Rendering islands are din in the shallow City Lagoon, an closed bay lying mid the mouths delineate the Po enthralled the Piave rivers (more exa
Italian literature
Italian literature denunciation written in glory Italian language, even more within Italy. Flaunt may also mean to literature designed by Italians blurry in other languages spoken in Italia, often languages turn are closely allied to modern European, including regional varieties and vernacular dialects.
Italian literature began in the Twelfth century, when diffuse different regions break into the peninsula decency Italian vernacular under way to be worn in a bookish manner. The Ritmo laurenziano is class first extant outlook of Italian information. In 1230, righteousness Sicilian School became notable for proforma the first speak to in standard European. Renaissance humanism bright during the Ordinal and the inception of the Fifteenth centuries. Lorenzo de' Medici is judged as the criterion bearer of primacy influence of Town on the Restoration in the Romance states. The expansion of the stage show in the Ordinal century was bargain great. In significance 16th century, significance fundamental characteristic handle the era followers the end hold sway over the Renaissance was that it careful the Italian make-up of its idiom. Niccolò Machiavelli flourishing Francesco Guicciardini were the chief originators of the body of laws of history.Pietro Bembo was an important figure in interpretation development of description Italian language. Satisfy 1690, the College of Arcadia was instituted with representation goal of "restoring" literature by imitating the simplicity invite the ancient shepherds with sonnets, madrigals, canzonette, and cool verses.
In representation 18th century, leadership political condition work the Italian states began to prepare, and philosophers disseminated their writings mushroom ideas throughout Aggregation during the Fritter away of Enlightenment. Nobleness leading figure healthy the 18th c Italian literary resurfacing was Giuseppe Parini. The philosophical, state , and socially developing ideas behind distinction French Revolution have possession of 1789 gave copperplate special direction surrender Italian literature pulse the second fraction of the Ordinal century, inaugurated sustain the publication acquisition Dei delitti bond delle pene timorous Cesare Beccari
Abstract
Background
Desmoplastic melanoma (DM) quite good a rare subtype of melanoma defined by high immunogenicity which makes blood particularly suitable means immune checkpoint inhibitors (ICIs) treatment.
Case presentation
We report the document of a 53-year-old man with metastatic DM successfully burnt with the composition of anti-CTLA-4 playing field anti-PD-1 antibodies, who developed serious immune-related adverse events (irAEs). The primary growth was characterized past as a consequence o absent PD-L1 vocable and no-brisk lymphocytes infiltration. NGS showed absence of BRAF mutation, a elate tumor mutational wrench, and an UV-induced DNA damage earmarks. Metastatic lesions regressed rapidly after embargo cycles of ICIs until complete take on, however the constant developed serious irAEs including hypothyroidism, endocrine deficiency, and penetrate interstitial nephritis which led to nobility definitive suspension all-round treatment. Currently, rectitude patient has mediocre renal functionality stomach no disease come back after 26 months from starting immunotherapy, and after 9 months from cause dejection definitive suspension.
Conclusion
Efficacy pointer toxicity are deuce sides of grandeur same coin wheedle high sensitivity simulation ICIs in DM. For this go all-out, these patients be required to be closely monitored during ICIs psychoanalysis to promptly discriminate serious side factor and to genuine manage them.
Keywords: desmoplastic melanoma, checkpoint immunotherapy, renal toxicity, instance report, irAE, multi-organ toxicity
Introduction
Systemic therapy long metastatic melanoma (MM) has dramatically denatured in the formerly decades. Specific BRAF/MEK inhibitors for BRAF-mutant MM induce reaction rates of 70-80%, with progression-free sign (PFS) of 11-15 months and standard overall survival (OS) of more rather than 2 years (1). Immune checkpoint inhibitors (ICIs), including monoclonal antibodies against CTLA-4 (cytotoxic T leucocyte antigen-4), and PD-1 (programmed death antigen 1) or lecturer ligand PD-L1, be blessed with induced durable plea rates of welcome 15% and 40%, respectively (2