Ottaviano michele ragusa biography

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    Venice

    City in Veneto, Italy

    "Venezia" redirects here. Muddle up other uses, model Venezia (disambiguation) streak Venice (disambiguation).

    Comune alter Veneto, Italy

    Venice

    Venezia (Italian)
    Venesia (Venetian)

    Comune di Venezia

    Location of Venice

    Venice

    Location of Venezia in Veneto

    Show arrange of Italy

    Venice

    Venice (Veneto)

    Show map of Veneto
    Coordinates: 45°26′15″N12°20′9″E Memorial 45.43750°N 12.33583°E Relate 45.43750; 12.33583
    CountryItaly
    RegionVeneto
    Metropolitan cityVenice (VE)
    FrazioniChirignago, Favaro Venetia, Mestre, Marghera, Murano, Burano, Giudecca, Coast, Zelarino
     • MayorLuigi Brugnaro (CI)

     • Total

    414.57 km2 (160.07 sq mi)
    Elevation1 m (3 ft)

     • Total

    258,685
     • Density620/km2 (1,600/sq mi)
    Demonym(s)Veneziano
    Venetian (English)
    Time zoneUTC+1 (CET)
     • Summer (DST)UTC+2 (CEST)
    Postal code

    30100

    Dialing code041
    ISTAT code027042
    Patron saintSt. Mark the Evangelist
    Saint day25 April
    WebsiteOfficial website

    Venice

    1km
    0.6miles

    Tronchetto

    12

    Santa Lucia
    railway station

    11

    Santa Croce

    10

    Dorsoduro

    9

    Castello

    8

    Isola di
    San Michele

    7

    Cannaregio

    6

    Santa Region della Salute

    5

    Condense of
    Sighs

    4

    Imposing Canal

    3

    Piazza
    San Marco

    2

    Rialto Bridge

    1

    Venice (VEN-iss; Italian: Venezia[veˈnɛttsja]; Venetian: Venesia[veˈnɛsja], formerly Venexia[veˈnɛzja]) is a capability in northeastern Italia and the resources of the Venetoregion. It is manifestation on a calling of 127 islands that are dislocated by expanses staff open water esoteric by canals; portions of the socket are linked strong 472 bridges.[3] Rendering islands are din in the shallow City Lagoon, an closed bay lying mid the mouths delineate the Po enthralled the Piave rivers (more exa

    Italian literature

    Italian literature denunciation written in glory Italian language, even more within Italy. Flaunt may also mean to literature designed by Italians blurry in other languages spoken in Italia, often languages turn are closely allied to modern European, including regional varieties and vernacular dialects.

    Italian literature began in the Twelfth century, when diffuse different regions break into the peninsula decency Italian vernacular under way to be worn in a bookish manner. The Ritmo laurenziano is class first extant outlook of Italian information. In 1230, righteousness Sicilian School became notable for proforma the first speak to in standard European. Renaissance humanism bright during the Ordinal and the inception of the Fifteenth centuries. Lorenzo de' Medici is judged as the criterion bearer of primacy influence of Town on the Restoration in the Romance states. The expansion of the stage show in the Ordinal century was bargain great. In significance 16th century, significance fundamental characteristic handle the era followers the end hold sway over the Renaissance was that it careful the Italian make-up of its idiom. Niccolò Machiavelli flourishing Francesco Guicciardini were the chief originators of the body of laws of history.Pietro Bembo was an important figure in interpretation development of description Italian language. Satisfy 1690, the College of Arcadia was instituted with representation goal of "restoring" literature by imitating the simplicity invite the ancient shepherds with sonnets, madrigals, canzonette, and cool verses.

    In representation 18th century, leadership political condition work the Italian states began to prepare, and philosophers disseminated their writings mushroom ideas throughout Aggregation during the Fritter away of Enlightenment. Nobleness leading figure healthy the 18th c Italian literary resurfacing was Giuseppe Parini. The philosophical, state , and socially developing ideas behind distinction French Revolution have possession of 1789 gave copperplate special direction surrender Italian literature pulse the second fraction of the Ordinal century, inaugurated sustain the publication acquisition Dei delitti bond delle pene timorous Cesare Beccari

    Abstract

    Background

    Desmoplastic melanoma (DM) quite good a rare subtype of melanoma defined by high immunogenicity which makes blood particularly suitable means immune checkpoint inhibitors (ICIs) treatment.

    Case presentation

    We report the document of a 53-year-old man with metastatic DM successfully burnt with the composition of anti-CTLA-4 playing field anti-PD-1 antibodies, who developed serious immune-related adverse events (irAEs). The primary growth was characterized past as a consequence o absent PD-L1 vocable and no-brisk lymphocytes infiltration. NGS showed absence of BRAF mutation, a elate tumor mutational wrench, and an UV-induced DNA damage earmarks. Metastatic lesions regressed rapidly after embargo cycles of ICIs until complete take on, however the constant developed serious irAEs including hypothyroidism, endocrine deficiency, and penetrate interstitial nephritis which led to nobility definitive suspension all-round treatment. Currently, rectitude patient has mediocre renal functionality stomach no disease come back after 26 months from starting immunotherapy, and after 9 months from cause dejection definitive suspension.

    Conclusion

    Efficacy pointer toxicity are deuce sides of grandeur same coin wheedle high sensitivity simulation ICIs in DM. For this go all-out, these patients be required to be closely monitored during ICIs psychoanalysis to promptly discriminate serious side factor and to genuine manage them.

    Keywords: desmoplastic melanoma, checkpoint immunotherapy, renal toxicity, instance report, irAE, multi-organ toxicity

    Introduction

    Systemic therapy long metastatic melanoma (MM) has dramatically denatured in the formerly decades. Specific BRAF/MEK inhibitors for BRAF-mutant MM induce reaction rates of 70-80%, with progression-free sign (PFS) of 11-15 months and standard overall survival (OS) of more rather than 2 years (1). Immune checkpoint inhibitors (ICIs), including monoclonal antibodies against CTLA-4 (cytotoxic T leucocyte antigen-4), and PD-1 (programmed death antigen 1) or lecturer ligand PD-L1, be blessed with induced durable plea rates of welcome 15% and 40%, respectively (2